Simplicef Tablet

Dosage: 100 mg
Quantity: 30 Count Vial
Sale price$57.90


Simplicef (cefpodoxime proxetil) is the first FDA-approved once-daily oral cephalosporin approved for veterinary use to treat skin infections in dogs. It is formulated to be convenient and an excellent value for large dogs.
* Sold per Tablet

What is Simplicef Tablet?

SIMPLICEF tablets are often prescribed for the treatment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis (group G, ß hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.

Who is Simplicef Tablet for?

For use in dogs.

Why use Simplicef Tablet? 

Features of Simplicef:

  • The first FDA-approved once-daily oral cephalosporin for veterinary use to treat skin infections in dogs
  • Cost-effective and convenient option for large dogs
  • Treats a variety of infections, including urinary tract, skin, ear, and respiratory tract infections
  • Convenient daily dosing

How does Simplicef Tablet work?

Simplicef is an effective treatment against most gram-negative and gram-positive bacteria. Cephalosporin antibiotics work by suppressing the growth of microorganisms like protozoa, fungi, or bacteria. Simplicef is easily-absorbed by the intestinal tract, then carried to the bloodstream to many of the body's tissues. For effectiveness, Simplicef should be administered for many days in a row. If any doses are missed or if the course of treatment is not completed, the infection may worsen or recur. Speak with your veterinarian if your pet's condition worsens or fails to improve following Simplicef treatment.



Active ingredient(s):

Cefpodoxime Proxetil

How is Simplicef Tablet sold?

Sold by the tablet in 100 mg or 200 mg strengths

What are the side effects of Simplicef Tablet?

While adverse reactions with cefpodoxime are rare, you could notice diarrhea, vomiting, or decreased appetite. If your pet exhibits any of these reactions, notify your veterinarian.

What special precautions are there?

  • Like other cephalosporins, this medication could cause a positive result in a direct Coombs' test.
  • Safety has not been proven for use in lactating, pregnant, or breeding dogs.

What to do if overdose?

Contact your vet or closest emergency animal hospital.

How can I store Simplicef Tablet?

Store at room temperature (15-30°C).

Helpful Tips:

Simplicef boasts a long half-life, which means that convenient, once-daily dosing is possible. This results in greater compliance and allows for better clinical outcomes.

Pharmacists are standing by to offer Pet Parent counseling regarding prescription medication purchased from Allivet before and after dispensing. Pharmacists on duty are available Monday-Friday, 9:30AM - 5:30PM EST and will be on call Saturday 12:00PM - 4:00PM EST for consultation.

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